- Salvage Yards, Junk Yards & Wrecker Service, Ephrata
- Sand Gravel & Aggregate, Ephrata
- Sandwich Shop Restaurants, Ephrata
- Savings Banks, Ephrata
- Secondary Schools, Ephrata
- Security & Surveillance System & Equipment, Ephrata
- Security Brokers & Dealers, Ephrata
- Security Services, Ephrata
- Senior Citizens Service & Health Organizations, Ephrata
- Septic Tanks & Systems, Ephrata - Wholesale, Dealers & Suppliers
- Septic Tanks & Systems Contractors & Designers, Ephrata
- Sewer & Drain Cleaning & Repair, Ephrata - Drain Cleaner & Installation Services
- Sewer Construction Contractors, Ephrata - Sewer Line, Pipe Installation & Repair Services
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- Sewing & Yarn Stores & Supplies, Ephrata
- Sharpening Service, Ephrata
- Shopping & Shopping Services, Ephrata
- Snack Foods, Ephrata
- Social Services & Welfare, Ephrata
- Speciality Food Stores, Ephrata
- Specialty Stores, Ephrata
- Sporting Goods Stores, Ephrata
- Stamp Collecting & Coin Dealers , Ephrata
- State Government, Ephrata
- Stocks & Bond Brokers, Ephrata
- Surveyor Services, Ephrata - Surveying Service
- Swimming Pools Repair, Service, Supplies, Sale & Installation, Ephrata
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